What finding is characteristic of chronic lymphocytic leukemia?

What finding is characteristic of chronic lymphocytic leukemia?

• A. Lymphocytosis
• B. Thrombocytopenia
• C. Hyperleukocytosis
• D. Granulocytopenia

Answer: (A)

Lymphocytosis is a hallmark finding in chronic lymphocytic leukemia (CLL). This condition is characterized by an accumulation of functionally incompetent lymphocytes, primarily B cells, which leads to an elevated lymphocyte count in the blood. In CLL, the lymphocyte count can be significantly higher than normal, often exceeding 5,000 cells per microliter, and it may reach levels much higher than that as the disease progresses. This increase in lymphocytes is not just quantitative; the lymphocytes themselves often appear morphologically characteristic, with a mature appearance but more irregularities in their shape and size compared to normal lymphocytes. Along with lymphocytosis, patients with CLL may exhibit symptoms like fatigue and increased susceptibility to infections due to the ineffective function of the accumulated lymphocytes. While thrombocytopenia, hyperleukocytosis, and granulocytopenia can be seen in various hematological conditions, they are not characteristic of CLL. In fact, thrombocytopenia is often a more complex finding related to other factors, such as bone marrow infiltration or autoimmune phenomena. Hyperleukocytosis indicates an increase in total white blood cells, which is often associated with acute leukemias rather than CLL. Gran

Lymphocytosis is a hallmark finding in chronic lymphocytic leukemia (CLL). This condition is characterized by an accumulation of functionally incompetent lymphocytes, primarily B cells, which leads to an elevated lymphocyte count in the blood. In CLL, the lymphocyte count can be significantly higher than normal, often exceeding 5,000 cells per microliter, and it may reach levels much higher than that as the disease progresses.

This increase in lymphocytes is not just quantitative; the lymphocytes themselves often appear morphologically characteristic, with a mature appearance but more irregularities in their shape and size compared to normal lymphocytes. Along with lymphocytosis, patients with CLL may exhibit symptoms like fatigue and increased susceptibility to infections due to the ineffective function of the accumulated lymphocytes.

While thrombocytopenia, hyperleukocytosis, and granulocytopenia can be seen in various hematological conditions, they are not characteristic of CLL. In fact, thrombocytopenia is often a more complex finding related to other factors, such as bone marrow infiltration or autoimmune phenomena. Hyperleukocytosis indicates an increase in total white blood cells, which is often associated with acute leukemias rather than CLL. Gran